منابع مشابه
Effects of Spray Drying and Spray Chilling on Ibuprofen Dissolution
The formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. Consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. Microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a ...
متن کاملMechanistic Understanding of Spray Drying
Purpose Spray drying is a growing technology in the pharmaceutical industry with several enabling applications in modern drug delivery. Its understanding is still vastly empirical, mainly in what relates to the particle formation step. Consequently, the design spaces are typically defined through costly experiments and their statistical interpretation. The purpose of this study is to examine th...
متن کاملModeling of Particle Formation during Spray Drying
A mathematical model for the evaporation of a single droplet, subjected to convective drying in a spray dryer was developed to study the transient phenomena of particle formation. During the constant-rate drying period, the governing equations and boundary conditions were transformed into a form containing Peclet number, Pe, as the main controlling parameter. A numerical solution was developed ...
متن کاملMicroencapsulation of peppermint oil during spray-drying
Essential oils are natural liquid products obtained from plants by hydroor steam distillation. Oils contain from dozens to hundreds of components – secondary plant metabolites. The essential oils are used as natural aromas in food and toiletry, and due to medicinal properties, many of them are used in conventional medicine and aromatherapy. Components of the essential oils are first of all mono...
متن کاملOptimization of Lycopene Microencapsulation by Spray Drying
The objectives of this work were to develop a new technique for lycopene microencapsulation by spray drying using dehumidified air as drying medium and to determine optimum operating conditions. A two-step optimization procedure was used. The encapsulation variables were selected in accordance with the PlackettBurman experimental design and were further optimized via response surface methodolog...
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ژورنال
عنوان ژورنال: Journal of Japan Oil Chemists' Society
سال: 1963
ISSN: 1884-2003
DOI: 10.5650/jos1956.12.383